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6.
J Investig Allergol Clin Immunol ; 29(4): 280-286, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30222112

RESUMO

BACKGROUND AND OBJECTIVE: Edema of the uvula (EU) may appear in isolation or in association with clinical manifestations such as urticaria, angioedema, and anaphylaxis. EU may lead to upper airway obstruction, provoking obstructive respiratory distress and asphyxia. Objective: We sought to investigate the etiology of and predisposing factors for EU in a large population of patients referred to an outpatient clinic. METHODS: In this 3-year follow-up cohort study, 171 patients presenting with EU were identified and classified as having isolated EU or nonisolated EU. The etiology of each patient's condition was studied, and possible predisposing factors were recorded. An allergology work-up and a statistical study (bivariate/multivariate analyses) were performed. RESULTS: The predisposing factors for both groups of EU patients were found to be different. The etiology of the problem was identified for most patients; allergy to Anisakis simplex was the most common cause in both groups. Nonsteroidal anti-inflammatory drugs and antibiotics were also found to be triggers in both groups. CONCLUSIONS: Isolated EU was associated with snoring, an elongated uvula, and having experienced previous episodes of EU. We found no associations between groups of EU patients and gender, obesity, smoking, alcohol consumption, personal and family history of atopy, and obstructive sleep apnea. Allergy to A simplex was the most commonly recorded cause.


Assuntos
Edema/epidemiologia , Edema/etiologia , Úvula/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Suscetibilidade a Doenças , Edema/diagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Razão de Chances , Medição de Risco , Fatores de Risco , Testes Cutâneos , Espanha/epidemiologia , Adulto Jovem
12.
Allergol. immunopatol ; 46(3): 253-262, mayo-jun. 2018. tab
Artigo em Inglês | IBECS | ID: ibc-172945

RESUMO

Component-resolved diagnosis based on the use of well-defined, properly characterised and purified natural and recombinant allergens constitutes a new approach in the diagnosis of venom allergy. Prospective readers may benefit from an up-to-date review on the allergens. The best characterised venom is that of Apis mellifera, whose main allergens are phospholipase A2 (Api m1), hyaluronidase (Api m2) and melittin (Api m4). Additionally, in recent years, new allergens of Vespula vulgaris have been identified and include phospholipase A1 (Ves v1), hyaluronidase (Ves v2) and antigen 5 (Ves v5). Polistes species are becoming an increasing cause of allergy in Europe, although only few allergens have been identified in this venom. In this review, we evaluate the current knowledge about molecular diagnosis in hymenoptera venom allergy


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Assuntos
Humanos , Animais , Alérgenos/imunologia , Venenos de Artrópodes/imunologia , Himenópteros/imunologia , Hipersensibilidade/diagnóstico , Mordeduras e Picadas de Insetos/imunologia , Alérgenos/análise , Alérgenos/química , Venenos de Artrópodes/química , Himenópteros/química , Hipersensibilidade/imunologia , Anafilaxia/imunologia
13.
Allergol Immunopathol (Madr) ; 46(3): 253-262, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-28739022

RESUMO

Component-resolved diagnosis based on the use of well-defined, properly characterised and purified natural and recombinant allergens constitutes a new approach in the diagnosis of venom allergy. Prospective readers may benefit from an up-to-date review on the allergens. The best characterised venom is that of Apis mellifera, whose main allergens are phospholipase A2 (Api m1), hyaluronidase (Api m2) and melittin (Api m4). Additionally, in recent years, new allergens of Vespula vulgaris have been identified and include phospholipase A1 (Ves v1), hyaluronidase (Ves v2) and antigen 5 (Ves v5). Polistes species are becoming an increasing cause of allergy in Europe, although only few allergens have been identified in this venom. In this review, we evaluate the current knowledge about molecular diagnosis in hymenoptera venom allergy.


Assuntos
Alérgenos/imunologia , Venenos de Artrópodes/imunologia , Himenópteros/imunologia , Hipersensibilidade/diagnóstico , Mordeduras e Picadas de Insetos/imunologia , Alérgenos/análise , Alérgenos/química , Animais , Venenos de Artrópodes/química , Humanos , Himenópteros/química , Hipersensibilidade/imunologia
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